Efficacy of Dentifrice containing 8.0% Arginine on Reduction of Dentinal Hypersensitivity

  • Maria Shakoor Abbasi Assistant Professor, Department of Prosthodontics, Altamash Institute of Dental Medicine, Karachi, Pakistan
  • Aamna Mansur Assistant Professor, Department of Prosthodontics, Khyber Medical University – Institute of Dental Sciences, Kohat, Pakistan
  • Sheheryar Minallah Trainee Medical Officer, Dental Department, Jinnah Postgraduate Medical Centre, Karachi, Pakistan
  • Ruqaya Shah Assistant Professor, Department of Oral and Maxillofacial Surgery, Jinnah Postgraduate Medical Centre, Karachi, Pakistan
Keywords: Dentifrice, Dentine, Hypersensitivity


Objective: To determine the efficacy of toothpaste containing 8.0% arginine in controlling dentinal hypersensitivity.

Materials and Methods: This cross-sectional study was conducted at the Altamash Institute of Dental Medicine, Karachi from January 2021 to August 2021. A total of 50 subjects with clinically diagnosed hypersensitivity who met the inclusion criteria were selected. Air hypersensitivity test was performed, and the response of patients was recorded using the Visual Analogue Scale (VAS). The subject's response was recorded at three-time intervals i.e., at baseline, immediately (after 1-minute) and ten days after the application. Paired sample and independent sample t-test were performed to analyse the results using SPSS version 24.

Results: Among 50 subjects with a mean age of 26.52 ± 4.74 years, 26 (52%) were male and 24 (48%) were female. The mean score of the air hypersensitivity test for 8.0% arginine at baseline, immediately after application and after usage for ten days was 8.26 ± 0.66, 4.24 ± 0.47 and 4.10 ± 0.51 respectively. Comparison of VAS scores showed significant decrease (p < 0.01) in hypersensitivity immediately after application and 10 days after application of 8.0% arginine.

Conclusion: Within the limitations of this study, it is concluded that a significant reduction in dentinal hypersensitivity was observed with the use of 8.0% arginine-containing toothpaste.